Maria Grazia Villani Selected Research

4-oxofenretinide

9/2008	Pharmacokinetics of oral fenretinide in neuroblastoma patients: indications for optimal dose and dosing schedule also with respect to the active metabolite 4-oxo-fenretinide.
3/2006	4-oxo-fenretinide, a recently identified fenretinide metabolite, induces marked G2-M cell cycle arrest and apoptosis in fenretinide-sensitive and fenretinide-resistant cell lines.
9/2004	Identification of the fenretinide metabolite 4-oxo-fenretinide present in human plasma and formed in human ovarian carcinoma cells through induction of cytochrome P450 26A1.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Maria Grazia Villani Research Topics

Disease

4	Neoplasms (Cancer) 05/2009 - 01/2003
3	Carcinoma (Carcinomatosis) 03/2006 - 02/2003
2	Neuroblastoma 09/2008 - 03/2006
1	Ovarian Neoplasms (Ovarian Cancer) 05/2009
1	Carcinogenesis 09/2004
1	Breast Neoplasms (Breast Cancer) 01/2003

Drug/Important Bio-Agent (IBA)

6	FenretinideIBA 05/2009 - 01/2003
3	RetinoidsIBA 05/2009 - 09/2004
3	4-oxofenretinideIBA 09/2008 - 09/2004
1	retinamideIBA 05/2009
1	AntioxidantsIBA 05/2009
1	Ascorbic Acid (Vitamin C)FDA LinkGeneric 05/2009
1	Butylated Hydroxyanisole (BHA)IBA 05/2009
1	Reactive Oxygen Species (Oxygen Radicals)IBA 05/2009
1	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 05/2009
1	cellular retinoic acid binding protein IIBA 09/2004
1	Cellular Retinol-Binding ProteinsIBA 09/2004
1	Proteins (Proteins, Gene)FDA Link 09/2004
1	cellular retinoic acid binding protein IIIBA 09/2004
1	Retinoic Acid 4-Hydroxylase (CYP26B1)IBA 09/2004
1	EnzymesIBA 09/2004
1	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 09/2004
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 02/2003
1	SphingolipidsIBA 02/2003
1	Vitamin A (Retinol)FDA LinkGeneric 01/2003
1	Pharmaceutical PreparationsIBA 01/2003